About Plectonic Biotech
Plectonic Biotech’s new class of programmable DNA-protein therapeutics function as molecular logic gates to selectively direct the immune response to the tumor. By applying our modular LOGIBODY® platform, we are building a pipeline of multi-specific T-cell-engaging biologics designed to overcome off-target toxicity and exponentially improve the therapeutic impact of immunotherapies using clinically validated targets. Initially focused on hematologic malignancies, our approach is designed to deliver an unprecedented level of precision and control, broadening the therapeutic window and improving patient outcomes in both liquid and solid tumors.
🌍 CurrentRoadmap to Clinical Application
Plectonic Biotech is working to bring Logibody therapies to clinical trials. We are currently running preclinical studies with a clear goal: to develop groundbreaking DNA-based therapeutics for targeted therapy.💲 2023SPRIND Funding and Scaling
Plectonic Biotech receives significant funding from SPRIND for the next 5 years to further develop the Logibody technology and advance it toward clinical applications. Research is executed with our partner Plectonic Logibody GmbH.
Article: Plectonic aspires to turn off cancer with LOGIBODies.
✔ Establishment of new laboratory and production facilities
✔ Scaling the technology for therapeutic applications
✔ Expansion of the team and strategic partnerships
🚀 2023Nature Nanotechnology Publication and Company Founding
The first scientific paper on Logibody technology is published in Nature Nanotechnology, confirming the method’s potential. Plectonic Biotech GmbH is officially founded.🧪 2019The Birth of Plectonic Biotech
The first research efforts on Logibody technology begin, initiated by the work of Benjamin Kick, Klaus Wagenbauer, and Jonas Funke. The goal is to leverage DNA-based protein structures for medical applications.
✔ Successful proof-of-concept experiments
✔ Initial pre-seed awards and substantial public research funding
Article: m4 Award 2019: 2.5 million euros for the fight against cancer and antibiotic resistance
🏭 2017Scalable Production of DNA in Large Quantities
Co-founder Benjamin Kick develops new methods for cost-efficient and highly scalable production of DNA nanostructures. This innovation paves the way for industrial applications of DNA nanotechnology.
Article: Biotechnological mass production of DNA origami⚡ 2015First Switchable DNA Origami
For the first time, DNA nanostructures are programmed to respond to external stimuli and perform mechanical movements. This highlights the potential for molecular switches and targeted therapeutic applications.
Article: Dynamic DNA devices and assemblies formed by shape-complementary, non–base pairing 3D components🔬 2009–2020Further Foundational Research in DNA Nanotechnology
Intensive research in DNA self-assembly, structural stability, and applicability leads to significant advancements. During this period, the following developments emerge:
✔ New methods for stabilizing DNA nanostructures
Articles:
Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation
Sequence-programmable covalent bonding of designed DNA assemblies
✔ Improved designs and blueprints for complex molecular architectures
Articles:
Rapid Folding of DNA into Nanoscale Shapes at Constant Temperature
Nature Communications
✔ Early applications for biomedical sensors and molecular machines
Article: Uncovering the forces between nucleosomes using DNA origami📐 20093D DNA Nanostructures Become a Reality
Co-founder Hendrik Dietz establishes the first three-dimensional DNA nanostructures. His research demonstrates that DNA can be used not only as an information carrier but also as a programmable structural material.
✔ 1982 – Ned Seeman constructs the first artificial DNA lattice structures, considered the precursor of DNA nanotechnology.
✔ 1991 – Eric Winfree and colleagues explore self-assembling DNA tiles as a basis for programmable nanostructures.
✔ 2004 – DNA cages and polyhedral structures demonstrate the potential of DNA for three-dimensional molecular architectures.
Article: Folding DNA into Twisted and Curved Nanoscale Shapes🧩 2006The Breakthrough of DNA Origami
Paul Rothemund publishes the concept of DNA origami, a method for folding DNA into precise nanoscale structures. This breakthrough opens up entirely new possibilities for constructing functional nanomaterials.
Article: Folding DNA to create nanoscale shapes and patterns